Scientists at Leeds are part of an international collaboration that has designed a protein that self-assembles into an artificial pore.

The protein sequence spontaneously transforms into a “transmembrane beta-barrel” – a tiny conduit or pore that embeds itself into a lipid membrane, mimicking its natural counterparts which are found in the walls of bacterial cells and enable nutrients, vitamins and strands of DNA to pass through.

There is intense scientific interest in the self-assembly of artificial pores as a way of exploiting the way nature moves “cargo” in and out of cells, for use in drug delivery or filtration technologies.

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